Maxim Berezovski, Ph.D.

Professor of Bioanalytical Chemistry Molecular Diagnostics Laboratory Department of Chemistry and Biomolecular Sciences University of Ottawa

Proteomics of extracellular vesicles

Abstract

This presentation will focus on new technologies for the affinity isolation of extracellular vesicles (EVs), the detection and counting of EVs, and the comprehensive analysis of EV biomarkers. A particular emphasis will be place on proteome and phosphoproteome analyses of microvesicles and exosomes derived from breast cancer cell lines. Among phosphoproteins identified, four enzymes were found to be associated with cancer: ATP citrate lyase (ACLY), phosphofructokinase-M (PFKM), sirtuin-1 (SIRT1), and sirtuin-6 (SIRT6). This study highlights that extracellular vesicles carry functional metabolic enzymes that could be further explored for early cancer diagnostic and therapeutic applications.

Biosketch

Maxim V. Berezovski is a Full Professor of Bioanalytical Chemistry at the University of Ottawa in Canada. He received a Ph.D. from York University (Canada) in 2005 and did an NSERC postdoc at the University of Toronto (Canada). His research focuses on bioanalytical chemistry, biological mass spectrometry, and molecular diagnostics. Prof. Berezovski published 98 articles, 5 book chapters, and 3 patents. He has an h-index of 39 with >5400 citations. He is an Editor for Molecular Therapy-Nucleic Acids and Editor for Cancers. Maxim was awarded a University of Ottawa’s Young Researcher Award, an Early Research Award from the Ministry of Research and Innovation of Canada, a Visiting Professorship from the Royal Netherlands Academy of Arts and Sciences, and a Friedrich Wilhelm Bessel Research Award from the Alexander von Humboldt Foundation of Germany. Before academia, he served as CEO of a pharmaceutical company for six years.

Date
Date(s) - October 12, 2022
6:00 pm - 8:00 pm

Emplacement / Location
Université de Montréal - Pavillon Jean Coutu (S1-151)