Alexander Makarov, Ph.D.

Director, Global Research Life Science Mass Spectrometry, Thermo Fisher Scientific, Germany

Past, Present and Future of Orbitrap Mass Spectrometry

Abstract

This talk provides a first-hand overview of the short but eventful history of Orbitrap mass spectrometry, from laying down the first principles of the technology to its current status as the leading technique for high-resolution, high mass accuracy quantitative analysis. While describing new possibilities arising from the recent extensions of two latest families of instruments, Orbitrap Fusion and Orbitrap Exploris, a special emphasis is placed on technical solutions that enhance quantitative, structural and high-mass analysis in these instruments. Discussion of future trends and perspectives of Orbitrap mass spectrometry is used to show its compelling potential as an (ultra-) high resolution platform not only for high-end proteomic applications but also for routine, translational and clinical analysis.

Biosketch

Alexander Makarov is Director of Research at the Life Science Mass Spectrometry Business Unit of Thermo Fisher Scientific in Bremen, Germany, Professor of High-Resolution Mass Spectrometry at Utrecht University in Netherlands and a Fellow of the Royal Society in the UK. He was the first to realize the potential of electrostatic traps to serve as high-resolution detectors for very accurate mass measurements. Following the development and commercialization of the Orbitrap technology, his research focuses on extending its capabilities as well as novel combinations with other advanced analytical techniques. He received numerous awards including the distinguished contribution to mass spectrometry from the American Society for Mass Spectrometry, and the Thomson Medal award.

Date
Date(s) - February 15, 2022
12:00 pm - 1:00 pm

Emplacement / Location
ZOOM