Shama Naz, PhD

Supervisor, Research
Metabolomics Core Facility
Faculty of Medicine, University of Ottawa 

LC-MS Based All Ion Fragmentation Method to Study the Urinary Metabolome of Patients with Asthma

Abstract

Mass spectrometry-based metabolomics in blood and urine has identified molecular signatures associated with both adult and paediatric asthma. The objective was to apply the developed AIF method and test a hypothesis that systemic therapies such as oral corticosteroids as well as disease severity are reflected in the urinary metabolome. Metabolomics identified a urinary metabotype of asthma driven by lower carnitine levels in an oral corticosteroid-independent manner. The carnitine transporter SLC22A5 was also decreased, suggesting carnitine metabolism as a potential therapeutic target.

Biosketch

Dr. Shama Naz received her PhD in medical chemistry from Universidad San Pablo CEU, Spain. Her academic training in metabolomics and Lipidomics platforms took place in leading international labs at the Korea Institute of Science and Technology (South Korea); Universidad San Pablo CEU (Spain); Karolinska Institute (Sweden); and Concordia University (Canada). She has extensive experience with global and targeted metabolomics and lipidomics, using GC-MS, LC-MS and CE-MS. Dr. Shama Naz, currently managing metabolomics core facility at the university of Ottawa.

Date
Date(s) - March 14, 2024
6:00 pm - 8:30 pm

Emplacement / Location
Université de Montréal - Campus MIL (Beer and pizza at 18h, conference at 19h in A-4502)