Alain Brunelle

Head of MS group, ICSN-CNRS, Gif-sur-Yvette, France

Biological applications of lipid imaging with cluster-TOF-SIMS and MALDI-TOF

This lecture intends to show the wealth of powerful information that can be obtained from the chemical analysis of biological surfaces, with several examples chosen among various applications such as the localization of xenobiotics, natural substances, lipid markers from genetic diseases and non-alcoholic fatty liver disease. The strengths and weaknesses of lipid imaging using TOF-SIMS and MALDI-TOF will also be compared, showing the complementarity between the two methods.