Laboratoire de Biologie Moléculaire et Cellulaire des Eucaryotes Institut de Biologie Physico-Chimique, UMR8226 CNRS, Sorbonne Universités UPMC, Paris, France
Systems biology of redox networks
Protein redox regulation and redox signaling mainly rely on a set of post-translational modifications of protein cysteine thiols essentially controlled by conserved oxidoreductases named thioredoxins and glutaredoxins. Using qualitative and quantitative large scale proteomic approaches in the unicellular green alga Chlamydomonas reinhardtii, we have unraveled an intricate redox network by identifying more than 1000 proteins regulated by thioredoxins, by nitrosylation or by glutathionylation. Moreover, we characterized 1052 thioredoxin-dependent regulatory sites and showed that these data constitute a valuable and unique resource for future functional studies of 602 Chlamydomonas proteins. These results provide evidence of a tremendous selectivity of redox post-translational modifications for specific cysteine residues.
Stéphane Lemaire is a CNRS Research Director, co-director of the proteomic platform and a group leader in Systems and Synthetic Biology of Microalgae at the Institute for Physico-Chemical Biology in Paris, France. His research focuses on innovative approaches to produce photosynthetic biofuels through a better understanding of the mechanisms of photosynthetic carbon fixation, the adaptation processes to environmental constraints and the redox signaling network that closely controls these processes. He received numerous distinctions and award including the 2006 CNRS Bronze medal for his seminal contributions on photosynthesis, redox regulation and signaling.
Date(s) - May 9, 2017
6:00 pm - 9:00 pm
Emplacement / Location
Morris and Rosalind Goodman Agora