Associate Professor, Dept. Chemistry and Chemical Biology McMaster University, Hamilton, ON Canada
Multiplexed Separations for Metabolomics: New Data Workflows for Biomarker Discovery
Comprehensive metabolite profiling (i.e., metabolomics) offers a holistic approach for understanding the phenotype of an organism on a molecular level that is closely associated with clinical outcomes. An introduction of capillary electrophoresis-mass spectrometry (CE-MS) technology will first be presented in the context of public health initiatives for human disease prevention. Examples will include the strategies to improve the performance of expanded newborn screening programs for early detection of rare yet treatable genetic disorders, as well as validation of lifestyle interventions that promote human health and/or reduce chronic disease risk. Recent strategies for enhancing sample throughput and data fidelity in metabolomics when analyzing volume-restricted or mass-limited biospecimens will also be discussed for biomarker discovery with quality assurance.
Philip Britz-McKibbin is a Professor at the Department of Chemistry and Chemical Biology and Cystic Fibrosis Canada Researcher at McMaster University in Hamilton, Canada. His research interests in bio-analytical chemistry and metabolomics include the design of novel analytical strategies to quantify and identify metabolites in biological samples, as well as characterization of their interactions with protein. Philip’s laboratory aims to discover new biochemical markers that support early detection and treatment of human diseases relevant to population health and preventative medicine with emphasis on inherited metabolic disorders. He is currently a Evaluation Group Member in Chemistry for NSERC Discovery Grant program, an editorial board member in Chemical Biology of Scientific Reports and a Founding Advisory Board Member of the US Chapter of the Metabolomics Society.
Date(s) - April 19, 2016
7:00 pm - 10:00 pm
Emplacement / Location
Morris and Rosalind Goodman Agora