Bonjour a tous,

Au nom du comité de sélection présidé par le Professeur Jeff Smith (U. Carleton) j’ai le plaisir de vous informer que Makan Golizeh (UQAM, groupe de Lekha Sleno) est le lauréat du prix Michel Bertrand 2015 parrainé par le MMSDG. Dans le cadre de cet événement, Makan Golizeh présentera un séminaire portant sur ses travaux de recherche mardi prochain le 17 novembre. Le titre et le résumé de sa présentation sont:
Dear colleagues,
On behalf of the selection committee presided by Professor Jeff Smith (U. Carleton), I have the pleasure to inform you that Makan Golizeh (UQAM, group of Lekha Sleno) is this year’s recipient of the Michel Bertrand award. As part of this special event Makan Golizeh will give a lecture on his research work this Tuesday November 17. The title and abstract of his presentation are provided below:

Best regards,

Pierre

 

Label-Free LC-MS/MS Analysis of Reactive Metabolite Protein Targets

Liver plays a predominant role in metabolic transformations and hepatic proteins are often targeted by reactive metabolites potentially leading to hepatotoxicity. Knowing what proteins are targeted is important to understand the mechanisms involved in this type of toxicity. An analytical approach was developed to identify reactive metabolite protein targets and their sites of modification using LC-MS/MS. This research was conducted in three phases to address the main challenges posed in this type of analysis: sample preparation, LC-MS/MS detection, and data analysis. The developed workflow was applied to conduct the first reliable identification and site-mapping of acetaminophen liver protein adducts from a complex proteome system by a global analysis approach.

Date
Date(s) - November 17, 2015
7:00 pm - 10:00 pm

Emplacement / Location
Morris and Rosalind Goodman Agora