Martin Dufresne

Candidat au Ph.D. en Chimie, Groupe Chaurand, Université de Montréal

Novel strategies for imaging mass spectrometry of low molecular weight compounds in thin tissue sections

Generic MALDI MS-based methods have been developed to image phospholipids in tissue sections. Specifically, sublimated matrix was used to reveal the abnormal accumulation and distribution of gangliosides in a mouse model of Hunter’s disease. To further expand the selectivity and sensitivity of imaging MS, two new methods were developed based on the affinity of metal cations to specific functional groups. Silver cations were used to specifically ionize and image olefin containing molecules such as fatty acids and cholesterol, whereas sodium doping coupled with a gold nanolayer was used to specifically ionize and image triacylglycerols and cholesterol esters. These new approaches were applied to the study of atherosclerosis and Alzheimer’s disease.

Date
Date(s) - November 8, 2016
7:00 pm - 10:00 pm

Emplacement / Location
Morris and Rosalind Goodman Agora