Thursday October 17, 2024 – Evgeniy Petrotchenko

Evgeniy Petrotchenko, MD, PhD

Associate director Segal Cancer Proteomics Centre, Lady Davis Institute, Montréal, QC, Canada

 

 

 

 

 

Structural proteomics of protein-protein and protein-drug interactions

 

Abstract

Combining protein chemistry methods with modern mass spectrometry has led to the emergence of the distinct field of structural proteomics. Multiple protein chemistry approaches, such as, surface modification, limited proteolysis, hydrogen–deuterium exchange, cross-linking and photo-affinity labeling, provide unique structural information on the protein systems studied. Experimental data from these various structural proteomics techniques offer valuable structural insights, especially in cases, where traditional structural biology methods, such as, X-ray crystallography, EM, NMR and, recently, machine learning-assisted homology modeling, fall short. Here, we will discuss method development and applications of various structural proteomics approaches for studying of protein structure, protein-protein and protein-drug interactions.

 

 

Biosketch

Evgeniy V. Petrotchenko received his M.D. from the Second Moscow Medical Institute, Moscow, Russia and his Ph.D. in bioorganic chemistry from the Institute of Bioorganic Chemistry of the National Academy of Sciences of Belarus, Minsk, Belarus. He conducted post-doctoral studies at the National Institute of Environmental Health Sciences, National Institutes of Health in Research Triangle Park, NC, USA and at the University of North Carolina at Chapel Hill, NC, USA. He joined Christoph Borchers lab as Research Associate at UNC-CH and, later, as Research Assistant Professor at the University of Victoria-Genome BC Proteomics Centre, University of Victoria, BC, Canada and as Associate Director of the Segal Cancer Proteomics Centre, Lady Davis Institute, Montréal, QC, Canada. He is co-founder of Creative Molecules Inc. and of the Symposium on Structural Proteomics.

Main research focus is structural proteomics method development and applications and, recently, metabolomics and clinical MS.

Date
Date(s) - October 17, 2024
6:00 pm - 8:00 pm

Emplacement / Location
Université de Montréal - Campus MIL (Beer and pizza at 18h, conference at 19h in A-4502)

Groupe de discussion en spectrométrie de masse de Montréal (GDSMM)

Le groupe de discussion sur la spectrométrie de masse de Montréal (GDSMM) est un organisme à but non lucratif qui offre un forum favorisant les interactions locales, nationales et internationales entre les scientifiques oeuvrant en spectrométrie de masse. Le GDSMM organise des séminaires scientifiques et des forums de discussion présentant les derniers développements en recherche fondamentale et appliquée en spectrométrie de masse. Une réunion annuelle du GDSMM qui regroupe les étudiants et les post-doctorants a lieu à Montréal chaque printemps et offre une opportunité unique de réseautage en plus d’accroitre la visibilité et la sensibilisation aux contributions locales en spectrométrie de masse.

Montreal mass spectrometry discussion group (MMSDG)

The Montreal mass spectrometry discussion group (MMSDG) is a not-for-profit organization that provides a forum to promote local, national and international interactions among scientists involved in mass spectrometry. MMSDG sponsors scientific seminars and forums to present the latest developments in basic and applied research in mass spectrometry. An annual MMSDG meeting that regroups students and postdoc is held every spring in Montreal, and provide a unique networking opportunity to participants and enhance the visibility and awareness of local contributions in mass spectrometry.